Senior Scientist Integrated Bioanalysis – Immunoassay Specialist

Job Title: SeniorScientistIntegrated BioanalysisImmunoassaySpecialist(levelD)

Location: Multiple locations (Sweden&UK)

AboutDiscovery Bioanalysis

Discovery Bioanalysis (DxBA) is a global department within Integrated Bioanalysis, Clinical Pharmacology & Safety Sciences, supporting AstraZeneca’s portfolio from early discovery through clinical development. The team applies advanced analytical technologies,including immunoassay, quantitative LC-MS, flow cytometry, multi-omics, and spatial biologyto generate high-confidence datasets for decision-making at key project milestones.

Discovery Bioanalysisis responsible fordeveloping and implementing bioanalytical strategies, ensuring robust and reliable data to guide candidateselectionand program progression. Working closely withcross-functional project-teams, the group provides comprehensive support across discovery, preclinical, and clinical phases, contributing to the advancement of therapies for complex diseases.

About the role

This is an opportunity for a motivated immunoassay expert to join our Integrated Bioanalysis (IBA) team inCambridge (UK)as a Senior Scientist.

As part of the Discovery Bioanalysis Team, you will develop andvalidatebespokeimmunoassays to assess pharmacokinetics and target engagement biomarkers across diverse therapeutic modalities. The role involves designing, executing, and transferring complex assays using advanced instrumentation to supportdiscovery,preclinical and clinical studies.You will ensure assays are fit for purposetomeet their intended context of use&will collaborate with internal and external partners, reviewingandanalyzingdata;and troubleshootingassay performance.As a Subject Matter Expert,youwillbe responsible forenhancingtheIBA reputation for scientific excellence by presenting at internal and external meetings, and publishing manuscripts.

Alongside the core laboratoryroleyou will have the opportunityasa Discovery Bioanalytical leadtowork withina dynamiccross-functionalteam in a matrixed environment, definingand executingon tailored & focused project-specific bioanalytical strategiessupporting decision-making and advancing the pipeline.You will work in close partnership with key stakeholders across the business,input to project strategy and delivery, managing expectationswhilstinterfacingwithexperienced and highly skilled bioanalytical scientist colleagues or our partnered labs. You will have the opportunitytoinfluencedecisions from early discovery through late-stage developmentandhave an immediate and lasting impact to our diverse pipeline.

Essentialrequirements:

• PhD or MSc (1–3 years’ experience), or BSc (3+ years’ experience) in immunology, molecular biology, or related field with significant relevant experience.

• Provenexpertiseas a subject matter expert in ligand-binding immunoassay techniques (expert level for MSD plus one of:Gyrolab,Simoa, SMC-Pro, NULISA, Ella).

• Demonstrated experience in leading bioanalytical project strategy.

• Experience developing robust,state-of-the-artassays for bioanalytical characterization of pharmacokinetics in preclinical and clinical studies, including complex large molecule bioanalysis (e.g., multi-specific antibodies, T cell engagers).

• Expertisein target engagement and occupancy biomarker assay development, including fit-for-purpose approaches.

• Demonstrated experience with total and free assay development to support dose modelling.

• Bioanalytical support for non-GLP IND-enabling studies, including assay qualification and tech transfer forGxP-like andGxPstudies.

• Ability to independently design, execute, and troubleshoot assays.

• Proficient in data analysis usingSoftmaxPro and MSD Workbench.

• Maintain high-quality documentation in electronic lab notebooks and prepare technical reports for regulatory submissions.

• Interpret complex datasets for key project decisions as part of cross-functional, multi-platform teams.

• Effective collaboration in a matrix environment and presentation of findings to scientific and management audiences.

• Agile and adaptable, able to manage multiple projects in a fast-paced setting.

• Strong publication record, communication, and organizational skills; proven accountability and teamwork.

Desirable for the role:

• Experience implementing AI and automation in laboratory and data workflows.

• Experience with ultrasensitive immunoassay platforms (e.g.,Simoa, SMC-Pro, NULISA).

• Experience acrossadditionalanalytical platforms (e.g., spatial, circulatory, molecular technologies such as imaging, cytometry, PCR).

• Background in developing and executing multiplexed immunoassays on Luminex.

• Previousinvolvement in pharmaceutical research with comprehensive understanding of drug discovery phases and related bioanalytical requirements.

• Basic coding skills for laboratory and data automation.

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challengeperceptions.That’swhy we work, on average, a minimum offourdays per week from the office. But thatdoesn'tmeanwe’renot flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.